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Objective: To study the clinical efficacy of modified Zhenwutang combined with Zhengji technique on cold-dampness arthralgia syndrome caused by knee osteoarthritis (KOA) at episode and the effect on inflammatory factors of joint fluid. Method: One hundred and forty-eight patients were randomly divided into control group and observation group by random number table. Patients in control group got celecoxib capsules, 0.2 g/time, 1 time/day, and Zhengji technique with lumbar positioning oblique pulling and finger pressing for 12 times, 1 time for every two days, 3 times/week. Patients in observation group got modified Zhenwutang, 1 dose/day, and the same Zhengji technique. The course of treatment was 4 weeks. Before and after treatment, western Ontario and McMaster University Osteoarthritis index (WOMAC), pain and swelling, index of severity of osteoarthritis (ISOA), local signs of knee joint and cold-dampness obstruction syndrome were scored, and the score of quality of life were discussed by arthritis impact measurement scale 2 (AIMS2-SF). And levels of interleukin-1 beta (IL-1β), IL-17, tumor necrosis factor-alpha (TNF-α), substance P (SP) and calcitonin gene-related peptide (CGRP) were detected. Result: The clinical efficacy in observation group was better than that in control group (Z=2.131, PPPβ, IL-17, TNF-α, SP and CGRP were higher than those in control group (PConclusion: Modified Zhenwutang combined with Zhengji technique can relieve clinical symptoms of patients with cold-dampness arthralgia syndrome caused by knee osteoarthritis (KOA) at episode, ameliorate joint function to improve patients' quality of life, reduce the expression of proinflammatory factors and neuropeptides in synovial fluid, so as to inhibit the inflammatory response and controlling clinical symptoms.
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<p><b>OBJECTIVE</b>To evaluate the clinical effect of traditional Chinese spinal orthopedic manipulation (TCSOM) in treating patients with functional abdominal pain syndrome (FAPS) in comparison with Pinaverium Bromide (Dicetel, PBD), and to assess a possible cause for FAPS.</p><p><b>METHODS</b>Eighty patients with FAPS were randomly and equally assigned to the TCSOM group and PBD group according to the random number table. All patients in the TCSOM group were treated with a maximum of 5 times of spinal manipulations. Patients in the PBD group were instructed to take 50 mg 3 times a day, consistently for 2 weeks. The symptoms of pre- and post-treatment were assessed on a visual analog scale (VAS) pain score. A symptom improvement rating (SIR) was implemented to evaluate the effects of the treatments.</p><p><b>RESULTS</b>The symptoms of 27 cases of the TCSOM group were relieved soon after the first TCSOM treatment and 9 cases were significantly improved. The VAS pain scores in the TCSOM group were significantly lower than those in the PBD group after 2 weeks treatment. According to the SIR based on VAS, the TCSOM group included 30 cases with excellent results, 7 cases with good, and 3 cases with poor. Adverse events to the treatment were not reported. Based on VAS, the PBD group reported 8 cases with excellent results, 10 cases with good and 22 cases with poor. There was a significant difference between the two groups (P<0.01).</p><p><b>CONCLUSIONS</b>The displacement of intervertebral discs and/or vertebra in the thoracic or lumbar region seems to be a contributing factor in the symptoms of FAPS. TCSOM is an effective treatment for FAPS.</p>
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<p><b>UNLABELLED</b>To evaluate clinical efficacy of acupressure at Jiaji points for irritable bowel syndrome (IBS) and explore its pathogenesis and treatment law.</p><p><b>METHODS</b>Sixty outpatient cases of IBS from 2010 to 2012 were selected and randomly divided into an acupressure group and a medication group, 30 cases in each one. The acupressure at Jiaji points was applied in the acupressure group while pinaverium bromide tablet was orally prescribed in the medication group. The bowel symptom scale (BSS) was adapted to sore symptoms before and after the treatment, the improvement rate was adopted and results were analyzed.</p><p><b>RESULTS</b>The difference of BSS score in two groups after the treatment had statistical significance (both P<0.01). The efficacy in the acupressure group was superior to that in the medication group, which had significant difference (P<0.01). The improvement rate was 90.0% (27/ 30) in the acupressure group, which was better than 50.0% (15/30) in the medication group (P<0.01). The location of abdominal pain in IBS was lower abdomen while treatment location was from 11th thoracic vertebra to 1st lumbar vertebra.</p><p><b>CONCLUSION</b>The acupressure at Jiaji points could balance yin and yang in spine to quickly relive symptoms of IBS. The attack of IBS has some relationship with thoracic and lumbar vertebras.</p>
Subject(s)
Adult , Aged , Female , Humans , Male , Middle Aged , Young Adult , Acupressure , Acupuncture Points , Irritable Bowel Syndrome , Therapeutics , Treatment OutcomeABSTRACT
<p><b>OBJECTIVE</b>To explore the cause and mechanism of irritable bowel syndrome, and to study the relationship between irritable bowel syndrome and unstable thoracolumbar vertebrae.</p><p><b>METHODS</b>From 2004 to 2006, 82 patients with irritable bowel syndrome were treated with manipulation thoracolumbar vertebrae without any drug using. Among the patients, 24 patients were male and 58 patients were female, ranging in age from 15 to more than 61 years.</p><p><b>RESULTS</b>After the treatment, 75 patients were cured and 7 patients improved.</p><p><b>CONCLUSION</b>Unstable thoracolumbar vertebrae is the cause of irritable bowel syndrome. It is a simple and effective way by manipulation on thoracolumbar vertebrae to release compression and stimulation on peripheral nerve and vascular for treating this disease.</p>